Ukusukela ngoDisemba ka-2019, i-COVID-19 ebangelwa sisifo esibuhlungu sokuphefumla i-Acute Respiratory Syndrome (SARS) isasazeke kwihlabathi liphela.Intsholongwane ebangela i-COVID-19 yi-SARS-COV-2, intsholongwane enemisonto enye kunye ne-RNA yosapho lwe-coronavirus.Ii-coronavirus ze-β zingqukuva okanye zimile okweqanda, 60-120 nm ububanzi, kwaye zihlala ziyi-pleomorphic.Ngenxa yokuba imvulophu yentsholongwane inemilo yeconvex enokufikelela kuwo onke macala kwaye ijongeka njenge-corolla, ibizwa ngokuba yi-coronavirus.Ine-capsule, kunye ne-S (i-Spike protein), i-M (i-protein ye-Membrane), i-M (iprotheni ye-matrix) kunye ne-E (i-Envelope protein) ihanjiswa kwi-capsule.Imvulophu iqulethe i-RNA ebophelela kwi-N (i-Nucleocapsid protein).Iprotheni ye-S yeI-SARS-COV-2iqulethe iiyunithi ze-S1 kunye ne-S2.I-domain ye-receptor-binding (RBD) ye-S1 subunit yenza usulelo lwe-SARS-COV-2 ngokuzibophelela kwi-angiotensin yokuguqula i-enzyme 2 (ACE2) kumphezulu weseli.
I-Sars-cov-2 inokosulela ukusuka komnye umntu ukuya komnye kwaye yosulela ngakumbi kune-sarS-COV, eyavela ngo-2003. Isasazwa ikakhulu ngamathontsi okuphefumla kunye nokunxibelelana nabantu ngokusondeleyo, kwaye inokosulelwa nge-aerosol ukuba ikho kwindawo engqongileyo. ngokungena moya kakuhle ixesha elide.Abantu badla ngokuba semngciphekweni wokosuleleka, kwaye ixesha lokufukamela yintsuku ezi-1 ukuya kwezili-14, uninzi lweentsuku ezi-3 ukuya kwezi-3.Emva kosulelo lwenoveli coronavirus, iimeko ezinobuthathaka ze-COVID-19 ziya kuba neempawu ikakhulu zomkhuhlane kunye nokhohlokhohlo olomileyo.I-COVID-19 iyosulela kakhulu kwaye iyosulela kakhulu kumanqanaba angenazo iimpawu zosulelo.Ukosuleleka yintsholongwane ye-Sars-cov-2 kunokubangela umkhuhlane, ukukhohlela okomileyo, ukudinwa kunye nezinye iimpawu.Izigulane ezinzima zihlala zihlakulela i-dyspnea kunye / okanye i-hypoxemia i-1 iveki emva kokuqala, kwaye izigulane ezinzima zingakhokelela kwi-syndrome yokuphefumula yokuphefumula, i-coagulopathy kunye nokungaphumeleli kwamalungu amaninzi.
Ngenxa yokuba i-sarS-COV-2 iyosulela kakhulu kwaye iyabulala, ikhawuleza, ichanekileyo kwaye ifanelekile iindlela zokuxilonga zokuchongwa kwe-SARS-COV-2 kunye nokubekwa bodwa kwabantu abosulelekileyo (kubandakanywa nabantu abosulelekileyo abangenazimpawu) sisitshixo sokufumanisa umthombo wosulelo, ukuthintela ukusuleleka kwintsholongwane. ikhonkco losulelo lwesifo kunye nokuthintela kunye nokulawula ubhubhane.
I-POCT, ekwaziwa ngokuba yitekhnoloji yokukhangela ecaleni kwebhedi okanye itekhnoloji yokufumanisa ixesha lokwenyani, luhlobo lwendlela yokufumanisa olwenziwa kwisampulu yesampulu kwaye inokufumana ngokukhawuleza iziphumo zokubhaqa ngokusebenzisa izixhobo eziphathwayo zokuhlalutya.Ngokubhekiselele ekubhaqweni kwe-pathogen, i-POCT ineenzuzo zesantya sokubona ngokukhawuleza kwaye akukho mqathango wesayithi xa kuthelekiswa neendlela zokufumanisa eziqhelekileyo.I-POCT ayinakukhawulezisa ukufunyaniswa kwe-COVID-19 kuphela, kodwa ikwathintela unxibelelwano phakathi kwabasebenzi abachongwayo kunye nezigulana kunye nokunciphisa umngcipheko wosulelo.Ngoku,Uvavanyo lwe-COVID-19Iindawo zaseTshayina ikakhulu zizibhedlele kunye namaziko ovavanyo lomntu wesithathu, kwaye abasebenzi abavavanyayo kufuneka bathathe iisampulu ngqo phambi kwabantu ukuze bavavanywe.Ngaphandle kwamanyathelo okhuseleko, ukuthatha isampulu ngokuthe ngqo kwisigulane kwandisa umngcipheko wosulelo kumntu ovavanyayo.Ke ngoko, inkampani yethu iphuhlise ngokukodwa ikhithi ukuze abantu benze isampulu ekhaya, enezibonelelo zokubonwa ngokukhawuleza, ukusebenza okulula, kunye nokubonwa ekhaya, kwisikhululo nakwezinye iindawo ngaphandle kweemeko zokhuseleko lwe-biosafety.
Ithekhnoloji ephambili esetyenziswayo yiteknoloji ye-immunochromatography, eyaziwa ngokuba yi-Lateral Flow assay (LFA), yindlela yokufumanisa ngokukhawuleza eqhutywa yi-capillary action.Njengetekhnoloji yokufumanisa ngokukhawuleza ekhulileyo, inomsebenzi olula, ixesha lokuphendula elifutshane kunye neziphumo ezizinzileyo.Ummeli wephepha le-colloidal gold immunochromatography (GLFA), elibandakanya ngokubanzi isampula, i-bond pad, ifilimu ye-nitrocellulose (NC) kunye ne-absorption pad yamanzi, njl. ifilimu ilungiswa kunye ne-antibody yokubamba.Emva kokuba isampuli ifakwe kwi-pad yesampuli, igeleza kwi-bonding pad kunye nefilimu ye-NC ngokulandelelana phantsi kwesenzo se-capillary, kwaye ekugqibeleni ifike kwi-pad e-absorbent.Xa isampulu iqukuqela kwiphedi yesibophelelo, into eza kulinganiswa kwisampulu iya kubophelela nge-antibody yeleyibhile yegolide;Xa isampuli ihamba nge-membrane ye-NC, isampuli eya kuvavanywa yabanjwa kwaye yalungiswa yi-antibody ebanjwe, kwaye iibhendi ezibomvu zavela kwi-membrane ye-NC ngenxa yokuqokelela i-nanoparticles yegolide.Ukufunyaniswa komgangatho okhawulezileyo we-SARS-COV-2 kunokufezekiswa ngokujonga amabhanti abomvu kwindawo yobhaqo.Ikhithi yale ndlela ilula ukuthengiswa kunye nokulinganisa, kulula ukuyisebenzisa kwaye iphendule ngokukhawuleza.Ilungele ukujonga abantu abaninzi kwaye isetyenziswa ngokubanzi ekubhaqweni kwenoveli yeCoronavirus.
Usulelo lwe-coronavirus entshalucelomngeni olukhulu elijongene nehlabathi.Ukuxilongwa ngokukhawuleza kunye nonyango lwangexesha lungundoqo ekuphumeleleni idabi.Ebusweni bosulelo oluphezulu kunye nenani elikhulu labantu abosulelekileyo, kubaluleke kakhulu ukuphuhlisa iikiti zokufumanisa ezichanekileyo kunye nokukhawuleza.Kuyaziwa ukuba phakathi kweesampulu ezisetyenziswa ngokuqhelekileyo, ulwelo lokuhlanjululwa kwe-alveolar lunelona zinga liphezulu lilungile phakathi kwe-pharyngeal swabs, amathe, isikhohlela kunye nolwelo lokuhlanjululwa kwe-alveolar.Okwangoku, olona vavanyo luxhaphakileyo kukuthatha iisampulu kwizigulana ezirhanelwa ngomqala ukusuka kwipharynx ephezulu, hayi indlela esezantsi yokuphefumla, apho intsholongwane inokungena lula.Intsholongwane inokufunyanwa nakwigazi, umchamo, kunye nendle, kodwa akusiyo indawo ephambili yosulelo, ngoko ke inani lentsholongwane liphantsi kwaye alinakusetyenziswa njengesiseko sokufumanisa.Ukongeza, njengoko i-RNA ingazinzanga kwaye kulula ukuyithoba, unyango olufanelekileyo kunye nokutsalwa kweesampulu emva kokuqokelela zizinto.
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Ixesha lokuposa: May-20-2022